Lipid-lowering Agents in Patients With Dermatomyositis and Polymyositis

  • End date
    Mar 27, 2022
  • participants needed
  • sponsor
    University of Sao Paulo
Updated on 27 January 2021


The use of lipid lowering agents in patients with idiopathic inflammatory myopathies is controversial. Therefore, the aim of the present study is to assess clinically and laboratory the impact of lipid-lowering agents in this population.


Impact of the lipid lowering agents on patients with dermatomyositis and polymyositis.

Condition Treatment Side Effects
Treatment Lipid-lowering agents (Artovastatin)
Clinical Study IdentifierNCT03092154
SponsorUniversity of Sao Paulo
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

fullfill all criteria of Bohan and Peter (1975)
age> 18 years
prednisone 0.25 mg/kg/day (or 15mg/ ay) in the last three months
without changing nutritional habits in the last three months, and during the study period
no change of lifestyle in the last three months, and during the study period

Exclusion Criteria

Patients with
disease relapsing
overlapping myositis
neoplasia associated myositis
diabetes mellitus
current and/or chronic infections
patients undergoing major surgery within six months prior to the study
pregnant patients
previous use of lipid-lowering agents in the last 6 months
in the use of cyclosporin, erythromycin, clarithromycin, fibrates, niacin, azole antifungals, cimetidine, diltiazem
active liver disease or persistent elevations of hepatic enzymes, with no apparent cause, exceeding three times the upper limit of normality
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