Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours (HyBT-H&N)

  • End date
    Dec 31, 2027
  • participants needed
  • sponsor
    University of Erlangen-Nürnberg Medical School
Updated on 25 February 2022


The aim of the present trial is to assess the prospective results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy with interstitial hyperthermia (iHT) in a group of selected patients where salvage surgery with clear resection margins was not possible.

Condition Locally Recurrent Head and Neck Cancer
Treatment brachytherapy, hyperthermia
Clinical Study IdentifierNCT03238378
SponsorUniversity of Erlangen-Nürnberg Medical School
Last Modified on25 February 2022


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Inclusion Criteria

Histologically confirmed recurrent carcinoma of the head and neck region
Stage rcT1-3
Tumor anatomy and location suitable for brachytherapy techniques
cN0/pN0 or rpN+ & R0 with <3 pos. LND & without invasion of capsula
ECOG 0-2
Previous radiation therapy up to at least 50 Gy
Previous radiation therapy completed more than 6 months ago
Written study-specific informed consent

Exclusion Criteria

rpN+ with >2 pos. LND or invasion of capsula
Pregnant or lactating women
Collagen vascular disease
The presence of congenital diseases with increased radiation sensitivity, for example Ataxia telangiectatica or similar
Psychiatric disorders
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