Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension

  • days left to enroll
  • participants needed
  • sponsor
    Medical University of Vienna
Updated on 23 April 2022
sleep disorder
sleep-disordered breathing
obstructive sleep apnea
central sleep apnea, cheyne-stokes breathing
central sleep apnea


There is evidence for a high prevalence of Sleep Disorder Breathing (SDB) in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Central Sleep Apnea, Cheyne-Stokes Breathing and Obstructive Sleep Apnea appear to occur in CTEPH. However, there is no information on the impact of CTEPH treatment modalities on concomitant SDB. Furthermore, the use of PAP therapy in CTEPH has not yet been investigated. CTEPH is a rare and serious disease and there may be a bidirectional association of SDB and CTEPH.

This study plans to investigate the prevalence of SDB in CTEPH and compare it to datasets of large epidemiological studies on SDB. Furthermore, the impact of CTEPH treatment on SDB will be analyzed and CTEPH patients for possible PAP treatment will be defined.

Condition Chronic Thromboembolic Pulmonary Hypertension, Sleep Disordered Breathing
Treatment Riociguat, Pulmonary Endarteriectomy, Ballon Pulmonary Angioplasty
Clinical Study IdentifierNCT03074539
SponsorMedical University of Vienna
Last Modified on23 April 2022


Yes No Not Sure

Inclusion Criteria

Recently diagnosed untreated CTEPH

Exclusion Criteria

Pulmonary Hypertension other than CTEPH
Previous diagnosis of SDB
Ongoing PAP treatment
Use of nasal oxygen
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