Predictive Impact of MMP2 and MMP9 Levels for Patients With Metastatic Kidney Cancer Treated With Anti-angiogenic Agents

  • STATUS
    Recruiting
  • days left to enroll
    70
  • participants needed
    50
  • sponsor
    Institut Paoli-Calmettes
Updated on 25 February 2022
cancer
sunitinib
pazopanib
metastatic renal cell carcinoma

Summary

Prospective research of Matrix Metalloproteinases (MMP) 2 and 9 as predictive biomarkers in metastatic kidney cancer patients treated with 2 anti angiogenic agents (Sunitinib or Pazopanib).

Description

The objective is to analyze the predictive impact of circulating MMP2 and MMP9 on the progression-free survival of patients with metastatic kidney cancer treated with anti-angiogenic agents (Sunitinib or Pazopanib) in comparison with two untreated cohorts (localized or oligometastatic cancer).

Prospective monocenter, open-label study

In the frame of disease management blood samples will be collected at different times of follow-up regarding disease status (localized, oligometastatic and metastatic) and tissue samples will be collected for patients scheduled for surgery.

Details
Condition Kidney Cancer
Treatment Blood and tumor samples
Clinical Study IdentifierNCT03185039
SponsorInstitut Paoli-Calmettes
Last Modified on25 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient male or female, aged of more than 18 years
Patient with any of the following conditions
Kidney cancer localized at diagnosis
Metastatic kidney cancer when anti-angiogenic therapy is initiated by Sunitinib or Pazopanib
Oligometastatic kidney cancer without systemic treatment (local treatment)
ECOG = 0 to 2
Patient affiliated to, or beneficiary of, the national social security
Patient having signed informed consent

Exclusion Criteria

Patient previously treated with anti-angiogenic agents
Person in an emergency situation, adult subject to a legal protection measure (a guardian, guardianship or safeguard of justice), or unable of expressing his / her consent
Impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons 4. History of malignant disease in the 5 years prior to inclusion (except basal cell carcinoma of the skin or epithelioma of the cervix in situ, or prostate cancer with a good prognosis (stage T <3 and Gleason <7)) accidentally discovered during the histological analysis of the tumor sample
- Pregnant or nursing women 6- Contraindications to the procedure of the
study
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