Last updated on May 2019

AROPE : Early Ovarian Reserve Decreased : Impact of Exposure to Persistent Endocrine Disruptors and Organic Solvents


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Female infertility
  • Age: Between 18 - 40 Years
  • Gender: Female

Inclusion Criteria :

For cases :

  • Women among news couples seeking to conceive (12 months tentative) and consulting among 4 fertility centers in Western France : Brest University hospital, Rennes University hospital, La Sagesse mutuality hospital, Nantes University hospital,
  • With at least one ovarian reserve decreased characteristic : Follicle antral counts (left and right ovaries) below 7 and/or anti-mullerian hormon (AMH) equal or below 1.1 ng/ml,
  • Age between 18 and 40 years,
  • Signed informed consent.

For each cases, two controls will be included matched on center and on age classes (5years). Controls will be :

  • Women among news couples seeking to conceive (12 months tentative) and consulting among 4 fertility centers in Western France : Brest University hospital, Rennes University hospital, La Sagesse mutuality hospital, Nantes University hospital,
  • With infertility examination considered as normal (AMH between 2 and 5 ng/ml, without genital malformations and with a menstrual cycle comprise between 27 and 32 days) and partner with an identified infertility etiology (migration test below 1 million spermatozoids progressive mobility),
  • Age between 18 and 40 years,
  • Signed informed consent.

Exclusion Criteria (cases and controls) :

  • Ovarian endometriosis,
  • SPOK,
  • annedal surgery antecedent,
  • cancer with chemiotherapy and radiotherapy antecedent,
  • Body mass index 35 kg/m,
  • Women with legal protection measures

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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