The Gut Microbiota of Bipolar and Depression

  • End date
    Nov 27, 2022
  • participants needed
  • sponsor
    First Affiliated Hospital Xi'an Jiaotong University
Updated on 25 February 2022
bipolar disorder
depressive disorder
depressed mood
major depressive disorder
psychiatric treatment
Accepts healthy volunteers


Background: The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. Investigators aim at elucidating the complement of the gut microbiome community for individuals with Major Depressive disorder (MDD) and Bipolar disorder (BD) relative to controls, and test for relationships with symptoms.

Methods: Investigators prospect to recruit subjects including patients and controls amount to 240. All subjects will be collected for blood and stool samples,assessed by clinical scales. Finally, analyzing the correlation among the metabolon in blood, microbiota in stool and clinical scales to obtain the possible interaction between diseases and gut microbiota.


Background: MDD (Major Depressive disorder) and BD (Bipolar disorder), whose specific pathogenesis is still unclear, are both a multi-factorial disease being caused by biological, psychological and social factors. Accumulating evidence suggests that gut microbiota play an important role in brain functions and in the pathogenesis of neuropsychiatric diseases, such as autism, anxiety, as well as depression. No study has thus far compared the human gut microbiota among BD, MDD and the healthy control (HC). The aim of this study is to compare the composition of fecal microbiota among BD, MDD and HC. Furthermore, investigators aim at identifying direct correlations between human fecal microbiota (as a proxy for gut microbiota) and symptoms.

  1. Investigators aim at recruiting human subjects in total 240, which including mania episode of bipolar disorder (40), depressive episode of bipolar disorder (40), mixed episode of bipolar disorder (40), first episode of major depressive disorder (40), recurrent episode of major depressive disorder (40), and healthy control (40). All patients, diagnosed according to the research criteria of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10, come from The First Affiliated Hospital of Xi'an Jiaotong University and controls are healthy volunteers.
  2. Collecting blood and stool samples, evaluating clinical scales including Montgomery-Asberg Depression Scale (MADRS), Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Measurement And Treatment Research To Improve Cognition In Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB), Clinical Global Impression (CGI) are all finished in first day after threshold.
  3. Measure the metabolon in blood such as S-CFA, and gut microbiota.
  4. Using Statistical Program for Social Sciences (SPSS) to compare general and clinical data among groups and analyze the correlation between the microbiota and symptoms.

Condition Bipolar Disorder, Major Depressive Disorder
Treatment Faecal genome
Clinical Study IdentifierNCT03062332
SponsorFirst Affiliated Hospital Xi'an Jiaotong University
Last Modified on25 February 2022


Yes No Not Sure

Inclusion Criteria

Conforms to the diagnosis of bipolar disorder or major depressive disorder
Take antibiotics continuously less than 3 days in recent 3 months

Exclusion Criteria

who is diagnosed with physical diseases and other mental diseases
pregnant or lactational women
who is diagnosed with mental retardation
Clear my responses

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