Volatile Anesthetic Protection Of Renal Transplants 2 (VAPOR-2)

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    Gertrude J. Nieuwenhuijs-Moeke
Updated on 1 February 2023
kidney transplant


To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors



To compare the effect of a sevoflurane based anaesthesia versus a propofol based anaesthesia on the incidence of delayed graft function in recipients of DCD and DBD donor kidneys.

Study design:

Prospective randomized controlled European multicentre clinical trial with two parallel groups

Study population:

Patients 18 years scheduled for kidney transplantation with a kidney from a DBD or DCD donor


Patients will be included and randomised to one of the following groups:

Group 1 PROP (control): Propofol: a propofol-remifentanil based anaesthesia. Group 2 SEVO (intervention): Sevoflurane: a sevoflurane-remifentanil based anaesthesia.

Main study parameters:

DGF defined as need of dialysis the first week after transplantation excluding one time dialysis for hyperkalemia Acute rejection episodes within the first year after transplantation Graft and patient survival GFR at 3 and 12 months PNF defined as a permanent lack of function of the allograft Length of hospital stay Postoperative complications of all kind kidney biomarkers (urine/plasma) mechanisms of protection/immunomodulation with anestheticanaesthetic agents

Condition Delayed Graft Function, Renal Outcome After Kidney Transplantation
Treatment Propofol, Sevoflurane
Clinical Study IdentifierNCT02727296
SponsorGertrude J. Nieuwenhuijs-Moeke
Last Modified on1 February 2023

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