Cerebral Microembolism in the Critically Ill With Acute Kidney Injury (COMET-AKI)

  • days left to enroll
  • participants needed
  • sponsor
    University Hospital Inselspital, Berne
Updated on 25 February 2022


The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Condition Cerebral Embolism
Treatment Renal replacement therapy
Clinical Study IdentifierNCT02621749
SponsorUniversity Hospital Inselspital, Berne
Last Modified on25 February 2022


Yes No Not Sure

Inclusion Criteria

> 18 yrs
Signed IC

Exclusion Criteria

Heart disease (PFO, ASD, VSD, severe valvular disease)
Atrial fibrillation
Cerebrovascular pathology
Missing temporal bone window
Allergy to plastic contained in the investigative device (transcranial Doppler)
Chronic kidney disease
Participation in another study
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