Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Swiss Paraplegic Centre Nottwil
Updated on 25 February 2022


The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.


Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch.

The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels.

In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST).

Pain related questionnaires will be obtained.

Condition Neuropathy;Peripheral
Treatment neurophysiology, neurophysiology
Clinical Study IdentifierNCT03037684
SponsorSwiss Paraplegic Centre Nottwil
Last Modified on25 February 2022


Yes No Not Sure

Inclusion Criteria

Group (1) patients with neuropathic pain
Group (2) patients with chronic postoperative pain

Exclusion Criteria

severe psychiatric disorder requiring hospitalisation in the past
any neurological disease other than the pain diagnosis
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