Effects of Neuromuscular Electrical Stimulation on Exercise Capacity in Respiratory Critically Ill Patients

  • STATUS
    Recruiting
  • End date
    Jul 1, 2021
  • participants needed
    40
  • sponsor
    Hospital Clinic of Barcelona
Updated on 25 January 2021

Summary

Neuromuscular electrical stimulation (NMES) implemented during the intensive care unit(ICU) stay may improve exercise capacity and prevent muscular weakness in critically ill patients with respiratory disease. Main objective: To evaluate, in respiratory critically ill patients, the effects of a conventional physiotherapy program with or without additional NMES applied only during the ICU stay on exercise capacity. Design: Randomized, controlled, double-blind clinical trial on patients (>18yo) with diagnosis on admission of acute or acute on chronic respiratory disease, on mechanical ventilation (MV) > 72h and expected MV > 24h. Intervention: Conventional physiotherapy with or without 30-minutes (5days/week) on quadriceps femoris and gluteus maximus. Patients in the control group will follow the same protocol but the device will not be activated. Measures: Demographic data, body composition through bioelectrical impedance analysis (BIA), and functional capacity before admission through Barthel scale will be registered upon inclusion. Exercise capacity through test sit-to stand, muscular strength through Medical Research Council (MRC) score and dynamometry, body composition through BIA, and functional capacity through Barthel scale will be obtained at ICU and hospital discharge.

Details
Condition Critical Illness Myopathy
Treatment SHAM, Neuromuscular electrical stimulation
Clinical Study IdentifierNCT03083652
SponsorHospital Clinic of Barcelona
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Critical Illness Myopathy?
Do you have any of these conditions: Do you have Critical Illness Myopathy??
Diagnosis at admission: acute or acute on chronic respiratory disease
Mechanical ventilation > 72h at inclusion
Expected mechanical ventilation > 24h
Informed consent

Exclusion Criteria

Patients re-admitted to ICU (no hospital discharge)
Exitus or transfer to another service/hospital
Respiratory instability [Inspired fraction of oxygen (FIO2) >60% or positive end-expiratory pressure (PEEP) >10 cmH2O] and/or hemodynamic instability [Mean arterial pressure ( MAP)<60mmHg although vasoactive drugs] during > 24h
Pregnancy
Neuromuscular disease before admission
Skin lesions
Limitation of therapeutic effort
Mental and/or physical limitation to understand/realize tests for evaluation
Clear my responses

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