Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    345
  • sponsor
    University Hospital, Toulouse
Updated on 21 January 2021

Summary

The current study seeks to examine the prevalence of amyloid pathology, among patients referred to the Toulouse Geriatric Frailty Clinic presenting objective memory impairment. We also aim to fully characterize the clinical progression of frail cognitively impaired patients presenting AD (Alzheimer Disease) pathology vs those who also present a cognitive impairment but do not have AD pathology.

Description

The COGFRAIL study is a monocentric study integrating the longitudinal follow-up of 345 individuals referred to the Toulouse Frailty Clinic during 2 years. The procedure consists in neuroimaging to diagnose the presence of amyloid plaques in the brains and permit earlier detection of Alzheimer's disease.

  • Visits will be scheduled at baseline, 1 and 2 years for a full neuropsychological, functional and physical evaluation.
  • At 6 and 18 months patients will be seen in consultation by a Geriatrician and research assistant for a medical check.
  • PET-Scan will be scheduled in the 2 months following inclusion for amyloid measurements. The MRI will be proposed, depending on the clinical relevance
  • A blood sample for biobank will be taken at visit 2 and at the end of the study

Details
Condition Frail Elderly
Treatment MRI and PET scan
Clinical Study IdentifierNCT03129269
SponsorUniversity Hospital, Toulouse
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Female and male individuals referred to the Toulouse Frailty Clinic with an objective memory impairment (CDR=0.5 or CDR=1)
Age 70 years
At least 1 Fried-criterion
Informed consent signed by the patient
Having an informant accompanying or available by phone
Individuals affiliated to a healthcare scheme
\- Willing to be informed in case of a new pathology discovered through medical examination

Exclusion Criteria

Individuals presenting severe visual or auditory difficulties which may interfere with the completion of neuropsychological and functional assessments
Presence of any pathology or severe clinical or psychological condition that, according to the investigator, might interfere with study results or may expose the participants to additional risks
Individuals who are robust according to the Fried criteria (0 criteria)
Individuals who are dependent (Activities of Daily Living (ADL) <4)
Individuals who have a major deterioration in global cognitive function (Mini Mental State Examination (MMSE) <20)
Subjects deprived of their liberty by administrative or judicial decision, or under guardianship or admitted to a healthcare or social institution (subjects in non-assisted living facilities could be recruited)
Exclusion criteria for MRI scanning
Claustrophobia
Trauma or surgery which may have left ferromagnetic material in the body, including pacemakers
History of neurosurgery or aneurism
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