Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults (COGFRAIL)
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- STATUS
- Recruiting
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- End date
- Dec 31, 2026
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- participants needed
- 345
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- sponsor
- University Hospital, Toulouse
Summary
The current study seeks to examine the prevalence of amyloid pathology, among patients referred to the Toulouse Geriatric Frailty Clinic presenting objective memory impairment. We also aim to fully characterize the clinical progression of frail cognitively impaired patients presenting AD (Alzheimer Disease) pathology vs those who also present a cognitive impairment but do not have AD pathology.
Description
The COGFRAIL study is a monocentric study integrating the longitudinal follow-up of 345 individuals referred to the Toulouse Frailty Clinic during 2 years. The procedure consists in neuroimaging to diagnose the presence of amyloid plaques in the brains and permit earlier detection of Alzheimer's disease.
- Visits will be scheduled at baseline, 1 and 2 years for a full neuropsychological, functional and physical evaluation.
- At 6 and 18 months patients will be seen in consultation by a Geriatrician and research assistant for a medical check.
- PET-Scan will be scheduled in the 2 months following inclusion for amyloid measurements. The MRI will be proposed, depending on the clinical relevance
- A blood sample for biobank will be taken at visit 2 and at the end of the study
Details
| Condition | Frail Elderly |
|---|---|
| Treatment | MRI and PET scan |
| Clinical Study Identifier | NCT03129269 |
| Sponsor | University Hospital, Toulouse |
| Last Modified on | 25 February 2022 |
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