Influence of Sex Hormones Variation During Third Trimester of Pregnancy and Post-partum on QT Interval Duration

  • STATUS
    Recruiting
  • End date
    Oct 28, 2022
  • participants needed
    60
  • sponsor
    French Cardiology Society
Updated on 28 January 2021

Summary

QT interval prolongation, corrected for heart rate (QTc), either spontaneous or drug-induced, is associated with an increased risk of torsades de pointes and sudden death. Women are at higher risk of torsades de pointes, particularly during post-partum and the follicular phase.

The aim of this study is to explore if QTc duration is prolonged during post-partum as compared to the 3rd trimester of pregnancy

Description

Sex steroid hormones are known to influence heart repolarization. Overall, estradiol is considered to promote QTc lengthening while progesterone and testosterone shorten QTc. New findings suggest more complex regulation of QTc by sex steroid hormones involving also follicle-stimulating hormone, which is associated to prolongation of QTc. Another important aim of this study is to study the influence of sex hormones on QTc duration.

Details
Condition Pregnancy
Treatment evaluation of QT interval duration, circulating sex hormones levels sample
Clinical Study IdentifierNCT02931695
SponsorFrench Cardiology Society
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult (>18 yo) pregnant women in their third trimester
Able to give her consent

Exclusion Criteria

Concomitant intake of QTcF prolonging drugs
Past medical history of cardiovascular or endocrino-metabolic conditions (except hypertension or diabetes)
QRS >120 msec on electrocardiogram
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