Last updated on April 2019

AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH


Brief description of study

The AURORA study will be conducted to confirm the efficacy and safety of cenicriviroc (CVC) for the treatment of liver fibrosis in adult subjects with NASH.

Detailed Study Description

The AURORA study will be conducted in 2 parts. Part 1 will examine the surrogate endpoint of improvement in fibrosis of at least 1 stage (nonalcoholic steatohepatitis clinical research network [NASH CRN]) and no worsening of steatohepatitis at Month 12. Subjects from Part 1 will continue into Part 2 and additional subjects will be newly randomized in Part 2 to determine long-term clinical outcomes composed of histopathologic progression to cirrhosis, liver-related clinical outcomes, and all-cause mortality.

Clinical Study Identifier: NCT03028740

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Franco Felizarta MD

Bakersfield, CA United States
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Precision Research Institute

Chula Vista, CA United States
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National Research Institute

Huntington Park, CA United States
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Cedars-Sinai Medical Group

Los Angeles, CA United States
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National Research Institute

Los Angeles, CA United States
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GastroIntestinal Biosciences

Los Angeles, CA United States
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eStudySite

Oceanside, CA United States
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Pasadena Liver Center

Pasadena, CA United States
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TriWest Research Associates

San Diego, CA United States
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Precision Research Institute

San Diego, CA United States
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UCSF School of Medicine

San Francisco, CA United States
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Upland Clinical Research

Upland, CA United States
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South Denver Gastroenterology

Englewood, CO United States
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Yale University

New Haven, CT United States
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Optimus Clinical Research

Coral Gables, FL United States
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Mayo Clinic College of Medicine

Jacksonville, FL United States
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Florida Research Institute

Lakewood Ranch, FL United States
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Orlando Immunology Center

Orlando, FL United States
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Advanced Medical Research

Port Orange, FL United States
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Tampa General Hospital

Tampa, FL United States
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Florida Medical Clinic

Zephyrhills, FL United States
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GI Specialists of Georgia

Marietta, GA United States
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Northwestern University

Chicago, IL United States
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Tandem Clinical Research

Marrero, LA United States
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Ochsner Medical Center

New Orleans, LA United States
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Louisiana Research Center

Shreveport, LA United States
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Johns Hopkins University

Baltimore, MD United States
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Digestive Disease Associates

Catonsville, MD United States
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Chevy Chase Clinical Research

Chevy Chase, MD United States
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Umass Memorial Medical Center

Worcester, MA United States
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Henry Ford Health System

Detroit, MI United States
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GastroIntestinal Associates

Flowood, MS United States
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Saint Louis University

Saint Louis, MO United States
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eStudySite - Las Vegas

Las Vegas, NV United States
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Amici Clinical Research

Martinsville, NJ United States
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New York Methodist Hospital

Brooklyn, NY United States
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Sing Chan, MD

Flushing, NY United States
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Beth Israel Medical Center

New York, NY United States
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Concorde Medical Group

New York, NY United States
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Mount Sinai Medical Center

New York, NY United States
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New York Medical College

Valhalla, NY United States
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Carolinas Medical Center

Charlotte, NC United States
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Duke University

Durham, NC United States
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Cumberland Research Associates

Fayetteville, NC United States
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Wake Research Associates

Raleigh, NC United States
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PMG Research of Winston-Salem

Winston-Salem, NC United States
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Options Health Research

Tulsa, OK United States
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VA Pittsburgh Healthcare System

Pittsburgh, PA United States
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University Medical Group

North Providence, RI United States
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University Gastroenterology

Providence, RI United States
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ClinSearch

Chattanooga, TN United States
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Gastro One

Germantown, TN United States
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Vanderbilt University

Nashville, TN United States
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ACRC Trials

Dallas, TX United States
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San Antonio Military Medical Center

Fort Sam Houston, TX United States
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Therapeutic Concepts

Houston, TX United States
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Centex Studies

Houston, TX United States
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Pioneer Research Solutions

Houston, TX United States
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Pinnacle Clinical Research

Live Oak, TX United States
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Centex Studies

McAllen, TX United States
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American Research Corporation

San Antonio, TX United States
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University of Utah

Salt Lake City, UT United States
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Inova Fairfax Medical Campus

Falls Church, VA United States
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Liver Institute of Virginia-Bremo

Newport News, VA United States
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VCU Medical Center

Richmond, VA United States
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Virginia Mason Hospital

Seattle, WA United States
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Harborview Medical Center

Seattle, WA United States
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Swedish Medical Center

Seattle, WA United States
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Froedtert Hospital

Milwaukee, WI United States
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hospital Italiano de Buenos Aires

Ciudad Autonoma de Buenos Aires, Argentina
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DIM Clinica Privada

Ramos Mejia, Argentina
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Nepean Hospital

Kingswood, Australia
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Flinders Medical Center

Bedford Park, Australia
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Austin Health

Heidelberg, Australia
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H pital Erasme

Brussels, Belgium
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LAIR Centre

Vancouver, BC Canada
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GI Research (GIRI)

Vancouver, BC Canada
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CHU de Strasbourg

Strasbourg cedex, France
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H pital Saint Antoine

Paris Cedex 12, France
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Centre M dical Odysseum

Montpellier cedex 2, France
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CHU de Montpellier

Montpellier cedex 5, France
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CHU Amiens-Picardie

Amiens Cedex 1, France
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EUGASTRO GmbH

Leipzig, Germany
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Queen Mary Hospital

Hong Kong, Hong Kong
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Tuen Mun Hospital

New Territories, Hong Kong
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Sunshine Hospitals

Secunderabad, India
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EMMS MC

Nazareth, Israel
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Christchurch Hospital

Christchurch, New Zealand
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Dunedin Hospital

Dunedin, New Zealand
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VitaMED

Bydgoszcz, Poland
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Clinic of Professor Gorbakov

Krasnogorsk, Russian Federation
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Infection Center

Koltsovo, Russian Federation
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Clinical Hospital #1-Smolensk

Smolensk, Russian Federation
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Modern Medicine Clinic

Moscow, Russian Federation
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Stavropol State Medical University

Novosibirsk, Russian Federation
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Union Clinic

Saint Petersburg, Russian Federation
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ECO Bezopasnost

Saint Petersburg, Russian Federation
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Research Institute of Influenza

Saint-Petersburg, Russian Federation
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Addenbrookes Hospital

Cambridge, United Kingdom
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Recruitment Status: Open


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