Last updated on July 2019

Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer


Brief description of study

This phase II randomized trial studies how well bupropion hydrochloride works in improving sexual desire in women with breast or gynecological cancer. Bupropion hydrochloride may work by boosting sexual desire, energy, or motivation without causing intolerable or undesirable side effects.

Detailed Study Description

PRIMARY OBJECTIVES:

I. Measure the ability of two dose levels of bupropion hydrochloride (bupropion), 150 or 300 mg of extended release, to improve sexual desire more than a placebo at 9 weeks (8 weeks on the target dose) as measured by the desire subscale of the female sexual function index (FSFI).

SECONDARY OBJECTIVES:

I. Evaluate the side effects of 150 and 300 mg bupropion extended release and differentiate these side effects from those observed in the placebo arm.

II. Evaluate the effect of 150 and 300 mg of bupropion extended release on the Patient Reported Outcomes Measurement Information System (PROMIS) fatigue scale, PROMIS sexual desire and satisfaction measure, patient health questionnaire (PHQ)-4, and the FSFI total score, at 5 and 9 weeks, as well as the desire subscale score of the FSFI at 5 weeks.

III. Evaluate the effect of 150 and 300 mg of bupropion extended release on the global impression of change scale and the patient?s perception of risk versus (vs.) benefit at 5 weeks (4 weeks at target dose) and 9 weeks (8 weeks at target dose).

OUTLINE: Patients are randomized to 1 of 3 arms.

ARM A: Patients receive bupropion hydrochloride orally (PO) once daily (QD) on days 1-63 and placebo PO QD on days 8-71.

ARM B: Patients receive bupropion hydrochloride PO QD on days 1-7 and 64-71, and twice daily (BID) on days 8-63.

ARM C: Patients receive placebo PO QD on days 1-7 and 64-71, and BID on days 8-63.

Clinical Study Identifier: NCT03180294

Find a site near you

Start Over

Randolph Hospital

Asheboro, NC United States
  Connect »

Northwest Cancer Clinic

Kennewick, WA United States
  Connect »

Saint Francis Cancer Center

Greenville, SC United States
  Connect »

Decatur Memorial Hospital

Decatur, IL United States
  Connect »

Kaiser Permanente-Oakland

Oakland, CA United States
  Connect »

Bryn Mawr Hospital

Bryn Mawr, PA United States
  Connect »

Mercy Hospital Springfield

Springfield, MO United States
  Connect »

Margaret R Pardee Memorial Hospital

Hendersonville, NC United States
  Connect »

Marshfield Clinic-Chippewa Center

Chippewa Falls, WI United States
  Connect »

Mercy Health Saint Mary's

Grand Rapids, MI United States
  Connect »

Geisinger Medical Group

State College, PA United States
  Connect »

Kaiser Permanente-Lone Tree

Lone Tree, CO United States
  Connect »

Saint Francis Medical Center

Cape Girardeau, MO United States
  Connect »

Mercy Hospital

Coon Rapids, MN United States
  Connect »

Saint Joseph Mercy Hospital

Ann Arbor, MI United States
  Connect »

South Carolina Cancer Specialists PC

Hilton Head Island, SC United States
  Connect »

Physicians' Clinic of Iowa PC

Cedar Rapids, IA United States
  Connect »

Adena Regional Medical Center

Chillicothe, OH United States
  Connect »

Kaiser Permanente-Anaheim

Anaheim, CA United States
  Connect »

Kaiser Permanente-Baldwin Park

Baldwin Park, CA United States
  Connect »

Kaiser Permanente-Bellflower

Bellflower, CA United States
  Connect »

Kaiser Permanente-Fontana

Fontana, CA United States
  Connect »

Kaiser Permanente-Fremont

Fremont, CA United States
  Connect »

Kaiser Permanente-Fresno

Fresno, CA United States
  Connect »

Kaiser Permanente - Harbor City

Harbor City, CA United States
  Connect »

Kaiser Permanente-Irvine

Irvine, CA United States
  Connect »

Kaiser Permanente-Cadillac

Los Angeles, CA United States
  Connect »

Kaiser Permanente-Modesto

Modesto, CA United States
  Connect »

Kaiser Permanente - Panorama City

Panorama City, CA United States
  Connect »

Kaiser Permanente-Redwood City

Redwood City, CA United States
  Connect »

Kaiser Permanente-Richmond

Richmond, CA United States
  Connect »

Kaiser Permanente-Riverside

Riverside, CA United States
  Connect »

Kaiser Permanente-Roseville

Roseville, CA United States
  Connect »

Kaiser Permanente - Sacramento

Sacramento, CA United States
  Connect »

Kaiser Permanente-San Francisco

San Francisco, CA United States
  Connect »

Kaiser Permanente San Leandro

San Leandro, CA United States
  Connect »

Kaiser Permanente-San Marcos

San Marcos, CA United States
  Connect »

Kaiser Permanente-San Rafael

San Rafael, CA United States
  Connect »

Kaiser San Rafael-Gallinas

San Rafael, CA United States
  Connect »

Kaiser Permanente-Santa Rosa

Santa Rosa, CA United States
  Connect »

Kaiser Permanente-South San Francisco

South San Francisco, CA United States
  Connect »

Kaiser Permanente-Stockton

Stockton, CA United States
  Connect »

Kaiser Permanente-Vallejo

Vallejo, CA United States
  Connect »

Kaiser Permanente-Walnut Creek

Walnut Creek, CA United States
  Connect »

Kaiser Permanente-Woodland Hills

Woodland Hills, CA United States
  Connect »

Penrose-Saint Francis Healthcare

Colorado Springs, CO United States
  Connect »

Swedish Medical Center

Englewood, CO United States
  Connect »

Kaiser Permanente-Rock Creek

Lafayette, CO United States
  Connect »

McKee Medical Center

Loveland, CO United States
  Connect »

Beebe Health Campus

Rehoboth Beach, DE United States
  Connect »

Nanticoke Memorial Hospital

Seaford, DE United States
  Connect »

Queen's Medical Center

Honolulu, HI United States
  Connect »

Centralia Oncology Clinic

Centralia, IL United States
  Connect »

Crossroads Cancer Center

Effingham, IL United States
  Connect »

Carle Cancer Center

Urbana, IL United States
  Connect »

Lawrence Memorial Hospital

Lawrence, KS United States
  Connect »

Associates In Womens Health

Wichita, KS United States
  Connect »

Flaget Memorial Hospital

Bardstown, KY United States
  Connect »

Saint Joseph Hospital East

Lexington, KY United States
  Connect »

Bronson Battle Creek

Battle Creek, MI United States
  Connect »

Saint Joseph Mercy Brighton

Brighton, MI United States
  Connect »

Saint Joseph Mercy Canton

Canton, MI United States
  Connect »

Saint Joseph Mercy Chelsea

Chelsea, MI United States
  Connect »

Hurley Medical Center

Flint, MI United States
  Connect »

Academic Hematology Oncology Specialists

Grosse Pointe Woods, MI United States
  Connect »

West Michigan Cancer Center

Kalamazoo, MI United States
  Connect »

Hope Cancer Clinic

Livonia, MI United States
  Connect »

Saint Mary Mercy Hospital

Livonia, MI United States
  Connect »

Lakeland Hospital Niles

Niles, MI United States
  Connect »

Saint Joseph Mercy Oakland

Pontiac, MI United States
  Connect »

Marie Yeager Cancer Center

Saint Joseph, MI United States
  Connect »

Munson Medical Center

Traverse City, MI United States
  Connect »

Metro Health Hospital

Wyoming, MI United States
  Connect »

Fairview Ridges Hospital

Burnsville, MN United States
  Connect »

Miller-Dwan Hospital

Duluth, MN United States
  Connect »

Unity Hospital

Fridley, MN United States
  Connect »

Abbott-Northwestern Hospital

Minneapolis, MN United States
  Connect »

Hennepin County Medical Center

Minneapolis, MN United States
  Connect »

Health Partners Inc

Minneapolis, MN United States
  Connect »

Monticello Cancer Center

Monticello, MN United States
  Connect »

New Ulm Medical Center

New Ulm, MN United States
  Connect »

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, MN United States
  Connect »

Regions Hospital

Saint Paul, MN United States
  Connect »

United Hospital

Saint Paul, MN United States
  Connect »

Lakeview Hospital

Stillwater, MN United States
  Connect »

Ridgeview Medical Center

Waconia, MN United States
  Connect »

Rice Memorial Hospital

Willmar, MN United States
  Connect »

Bozeman Deaconess Hospital

Bozeman, MT United States
  Connect »

Community Medical Hospital

Missoula, MT United States
  Connect »

CHI Health Saint Francis

Grand Island, NE United States
  Connect »

Cone Health Cancer Center

Greensboro, NC United States
  Connect »

Annie Penn Memorial Hospital

Reidsville, NC United States
  Connect »

Indu and Raj Soin Medical Center

Beavercreek, OH United States
  Connect »

Miami Valley Hospital South

Centerville, OH United States
  Connect »

Bethesda North Hospital

Cincinnati, OH United States
  Connect »

Riverside Methodist Hospital

Columbus, OH United States
  Connect »

Grant Medical Center

Columbus, OH United States
  Connect »

Doctors Hospital

Columbus, OH United States
  Connect »

Miami Valley Hospital

Dayton, OH United States
  Connect »

Dayton Physicians LLC-Atrium

Franklin, OH United States
  Connect »

Dayton Physicians LLC-Wayne

Greenville, OH United States
  Connect »

Wayne Hospital

Greenville, OH United States
  Connect »

Greater Dayton Cancer Center

Kettering, OH United States
  Connect »

First Dayton Cancer Care

Kettering, OH United States
  Connect »

Kettering Medical Center

Kettering, OH United States
  Connect »

OhioHealth Mansfield Hospital

Mansfield, OH United States
  Connect »

Marietta Memorial Hospital

Marietta, OH United States
  Connect »

Knox Community Hospital

Mount Vernon, OH United States
  Connect »

Licking Memorial Hospital

Newark, OH United States
  Connect »

Southern Ohio Medical Center

Portsmouth, OH United States
  Connect »

Saint Ann's Hospital

Westerville, OH United States
  Connect »

Geisinger Medical Center

Danville, PA United States
  Connect »

Lewistown Hospital

Lewistown, PA United States
  Connect »

Riddle Memorial Hospital

Media, PA United States
  Connect »

Paoli Memorial Hospital

Paoli, PA United States
  Connect »

Community Medical Center

Scranton, PA United States
  Connect »

Lankenau Medical Center

Wynnewood, PA United States
  Connect »

Gibbs Cancer Center-Gaffney

Gaffney, SC United States
  Connect »

Saint Francis Hospital

Greenville, SC United States
  Connect »

Spartanburg Medical Center

Spartanburg, SC United States
  Connect »

Logan Regional Hospital

Logan, UT United States
  Connect »

Duluth Clinic Ashland

Ashland, WI United States
  Connect »

Aurora Health Center-Fond du Lac

Fond Du Lac, WI United States
  Connect »

Aurora Cancer Care-Grafton

Grafton, WI United States
  Connect »

Aurora BayCare Medical Center

Green Bay, WI United States
  Connect »

Aurora Cancer Care-Milwaukee

Milwaukee, WI United States
  Connect »

Aurora Sinai Medical Center

Milwaukee, WI United States
  Connect »

Cancer Center of Western Wisconsin

New Richmond, WI United States
  Connect »

Aurora Cancer Care-Racine

Racine, WI United States
  Connect »

HSHS Saint Nicholas Hospital

Sheboygan, WI United States
  Connect »

Broadlawns Medical Center

Des Moines, IA United States
  Connect »

Methodist West Hospital

West Des Moines, IA United States
  Connect »