Adequacy of Perioperative Cefuroxime Dosage According to the BMI

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    Universitätsklinikum Hamburg-Eppendorf
Updated on 22 January 2021


This study evaluates the dosage of perioperative cefuroxime for obese patients. Dosage was increased if the BMI was over 30kg/mm and as well over 50kg/mm. Drug levels were measured in blood and tissue.


Cefuroxime is an often used antibiotic for surgery antibiotic prophylaxis to avoid surgical wound infection. In this study the dosage of cefuroxime was adjusted to the BMI:

less than 30kg/mm: 1,5g 31-50kg/mm: 3,0g more than 50kg/m*m: 4,5g

Cefuroxime was applicated 30 to 60 minutes before the begin of surgery. Drug Levels in blood and fat tissue were measured at skin cut (30-60 minutes after application of Cefuroxime), 45 minutes after skin cut (75-105 minutes after minutes after application of Cefuroxime) and at the end of surgery (up to 150 minutes after application of Cefuroxime) .

The hypothesis of this study is that adequate drug levels are reached in all groups.

Condition Obesity; Drug, Obesity; Drug
Treatment Cefuroxime 1,5g, Cefuroxime 3g, Cefuroxime 4,5g
Clinical Study IdentifierNCT03141476
SponsorUniversitätsklinikum Hamburg-Eppendorf
Last Modified on22 January 2021

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