Study of Letrozole in Recurrent Gliomas

  • End date
    Jun 22, 2023
  • participants needed
  • sponsor
    University of Cincinnati
Updated on 22 September 2021


The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.


Nine to forty-two (42 patients only if every cohort required expansion) total patients are planned for this phase 0/1 study to explore the ability of letrozole to penetrate the blood brain barrier and gliomas.

Condition Malignant neoplasm of brain, Brain Tumor (Pediatric), Brain Cancer, Brain Tumor, brain tumors
Treatment Letrozole Oral Tablet
Clinical Study IdentifierNCT03122197
SponsorUniversity of Cincinnati
Last Modified on22 September 2021


Yes No Not Sure

Inclusion Criteria

Recurrent brain glioma with plan for resection or biopsy
ECOG 0-2
Adequate labs

Exclusion Criteria

Receiving other investigational agents
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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