TMS for Complex Regional Pain Syndrome

  • End date
    Jun 29, 2024
  • participants needed
  • sponsor
    Stanford University
Updated on 4 July 2022
pain disorder
pain syndromes
transcranial magnetic stimulation


The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.

Condition Complex Regional Pain Syndromes
Treatment Transcranial Magnetic Stimulation (TMS)
Clinical Study IdentifierNCT03137472
SponsorStanford University
Last Modified on4 July 2022


Yes No Not Sure

Inclusion Criteria

Age 18-70
Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months
Average pain level reported on Numerical Rating Scale meets entry criteria
Ability to perform the experimental task and procedures

Exclusion Criteria

MRI contraindication (metal implants or devices, claustrophobia)
TMS Contraindication (eg metal implant or devices near the site of stimulation)
History of epilepsy
History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher
Neurologic illness that would interfere with brain integrity
Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher
Currently pregnant or planning to become pregnant
On going legal action or disability claim
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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