TRT in Combination With Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males

  • STATUS
    Recruiting
  • End date
    Oct 21, 2022
  • participants needed
    56
  • sponsor
    Kessler Foundation
Updated on 21 January 2021
electrical stimulation
quadriplegia
spinal cord disorder
spinal injury

Summary

The aim of this study is to understand what happens to muscle and bone in spinal cord injured males after four months of training using stand training, with body weight support (BWS), with testosterone replacement therapy (TRT), and electrical stimulation (ES). Specifically, researchers will investigate nerve, muscle, and bone changes in the lower limbs in response to stand training and ES when combined with TRT compared to i) standing alone with TRT; ii) stand training alone with placebo; iii) stand training alone and ES with placebo.

Description

Primary Aim:

To assess the effects of our novel tri combination Activity-Dependent Rehabilitation model approach on muscle volume of the lower limbs.

Secondary Aims:

i) To better define the mechanisms that contribute to changes in muscle.

Preliminary data from animal studies have shown increased expression of Activin receptor IIB and increased nuclear localization of Smad2 and Smad3 after SCI and that these adverse changes are reversed by androgens. Additional studies will examine mRNA levels for myostatin, its receptor and its inhibitors (e.g., follistatins) and determine nuclear levels of Smad2 and Smad3. We will also measure resting energy expenditure to confirm that changes in muscles mass correspond to anticipated metabolic effects.

ii) To evaluate the changes in bone and bone structure with Stand Training with TRT and ES.

Individuals with SCI not only lose motor and/or sensory function, they experience dramatic muscle and bone loss. Locomotor training, an activity-based intervention that engages the neuromuscular system below the level of lesion for standing and walking enhances EMG activity and has shown modest improvements in muscle without any attenuation in bone density [172-177]. Dynamic stand training, an important component of locomotor training, provides sensory feedback related to standing and bilateral weight bearing, resulting in bilateral muscle activation via central pathways through the spinal cord [161,178-181]. Thus, the stand retraining component provides a physiologically relevant multi-muscle activation through central pathways, dynamic gravity opposed loading of the legs and additional task specific activation of the muscles [161,162,179]. Functional electrical stimulation is a method of exercise that has been employed in the SCI population and has demonstrated success in improving muscle, with less conclusive evidence for its effect on bone albeit there has been speculation that although slowing or preventing bone loss may be feasible after SCI, reversing such bone loss (i.e. restoring bone) is not possible, although the evidence is primarily from applying FES to single muscles [151,171]. TRT has been shown to offer a logical, efficacious, and cost-effective intervention to, in part, counteract these untoward body composition, metabolic, and functional sequelae of relative hypogonadism in those with chronic SCI [37]. In addition, testosterone alone has been shown to increase muscle mass, muscle strength, and bone in androgen-deficient men and older men with low testosterone levels [182,183]. The model of compressive loads generated during the combination of stand retraining and multi muscle ES will be multi-directional and will increase muscle strength and the forces applied to the hip, femur and tibia bones. We anticipate that the model of standing plus TRT will increase muscle mass and strength more than standing alone. The combination of multi muscle TRT+ES while stand training will further increase muscle strength compared to either arm alone, resulting in an increased synergistic response of benefit which will surpass the threshold needed to significantly increase bone restoration [102,184,185].This novel tri-combination synergistic approach of TRT, ES, and Stand Training is being hypothesized to increase muscle mass and strength to a greater extent than that of each alone or than that of only two of these interventions. Measurements of muscle torques will be obtained to demonstrate a quantifiable relationship between muscle strength and bone mass.

Details
Condition Spinal Cord Injury, Myelopathy, Trauma, Spinal Cord Injuries, Wounds, Spinal Cord Disorders
Treatment electrical stimulation, Stand Training, Testosterone Gel applied by a pump
Clinical Study IdentifierNCT02317640
SponsorKessler Foundation
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 58 yrs?
Are you male?
Do you have Spinal Cord Injury?
Do you have any of these conditions: Spinal Cord Disorders or Spinal Cord Injury or Spinal Cord Injuries or Myelopathy or Wounds or Trauma?
Must be a male between 18 and 58 years old
Must have a spinal cord injury at a neurological level of injury between the C6-T10 level and an impairment grade A, B, or C, according to the American Spinal Injury Association (ASIA) Impairment Scale. If a person with quadriplegia their motor level will be used instead of neurological level. As a quadraplegic the motor level must be between C6-T10
Must be able to tolerate electrical stimulation and must show visible muscle contraction to an electrical stimulus
Must be wheelchair reliant for more than 75% of the time
Must have low testosterone levels (300-325 ng/dL) as determined by a blood test done at the baseline study visit

Exclusion Criteria

Taking spasticity medication (i.e., baclofen). It may be possible that participant can be weaned off of the spasticity medication prior to starting entry into the study. This would be under the guidance of the study physician
Less than 6 months or greater than 10 years post injury
A score >3 on the Modified Ashworth Scale as determined by study staff
Bone density measurement for the knee is at or below .5755 gm/cm2 as recorded by study staff
Weigh more than 225 lbs
Taller than 6 feet 3 inches
Presence of a cardiovascular disease
Presence of pulmonary disease
Presence of recent lower limb fractures
Presence of severe contractures
Presence of lower extremity deep vein thrombosis (within the last three months) or other major medical illness
Taking medications known to influence bone metabolism as determined by study staff review of medications
A major gastrointestinal problem such as swallowing or gastrointestinal reflux disease
Heart rate or rhythm problems
A pacemaker
Had spinal fusion, must have approval from the referring physician to receive ES - assisted standing prior to acceptance into the study
As determined by study staff and review of medications, taking medication known to affect my level of testosterone
A PSA greater than or equal to 4.0 ng/ml as determined by blood tests during screening visit
An elevated PSA or asymmetry or hardening of prostate as determined by blood tests and digital rectal examination at screening visit
Any known heart or blood vessel problems (cardiovascular disease)
An acute illness of any cause
History of anabolic steroid use as determined by study staff review of participant's medical records
Have a hematocrit greater than or equal to 55 as measured by the study team
Have an abnormal liver function test from the hepatic panel (greater than 2.5 times the normal value) as measured by the study team
Have an abnormal digital rectal exam (DRE) at baseline suggestive of malignancy
Currently abuse alcohol or drugs
Have a significant psychological disorder
Have a history of or a current malignancy
Wish to contribute to the conception of a child
If any of the following occurs in the experimental group following initiation
of testosterone replacement therapy participation will be terminated
Hematocrit greater than or equal to 55
Abnormal liver function test from the hepatic panel (greater than 2.5 times the normal value)
Worsening of any sleep disorder, as determined by the Investigators
A PSA greater than or equal to 4.0 ng/ml
Worsening of mood disorders; i.e. anger and depression as determined by the investigators
Planning to contribute to the conception of a child during the study period
Have participated in an electrical stimulation or TRT study in the previous 3 months
Clear my responses

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