Last updated on June 2019

Study of Acarbose in Longevity


Brief description of study

The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.

Detailed Study Description

Acarbose, an FDA approved drug for the treatment of type 2 diabetes, has known effects on glucose metabolism. Evidence from mice indicates that acarbose may prolong lifespan. In humans, acarbose improves inflammatory markers and reduces cardiovascular events. Consequently, acarbose is of interest in clinical translational aging research since it may influence fundamental processes that contribute to age-related diseases. The study described herein is an exploratory study to examine the effect of acarbose treatment on the biology of aging in humans. Specifically, the investigators plan to study whether treatment with a 10 week course of acarbose will alter the gene expression profile in adipose tissue and muscle in older adults in pathways that are known to be affected by human aging, in a placebo-controlled crossover study.

Clinical Study Identifier: NCT02953093

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


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