Gluten Challenge in Celiac Disease
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- STATUS
- Recruiting
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- End date
- Aug 24, 2028
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- participants needed
- 10
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- sponsor
- Oslo University Hospital
Summary
Up till 30 participants with celiac disease on a glutenfree diet are asked to consume gluten containing cookies or bread for 3 days.
Questionnaires and sampling of blood is done before, during and after.
Description
Before and 6 days after start of gluten challenge, blood samples will be collected and analysed by using HLA-tetramers to identify and purify CD4+ gluten-specific T cells by flow cytometry. T cells will undergo transcriptome analysis to get an insight in signalling of antigen-specific cells. Other cell populations like CD8+ T cells and T cells will also be analyzed by flow cytometry.
Details
| Condition | Celiac Disease |
|---|---|
| Treatment | Gluten challenge |
| Clinical Study Identifier | NCT02464150 |
| Sponsor | Oslo University Hospital |
| Last Modified on | 24 February 2022 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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