Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD
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- STATUS
- Recruiting
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- End date
- Jul 25, 2026
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- participants needed
- 200
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- sponsor
- University of California, San Francisco
Summary
The transition from chronic kidney disease (CKD) to end-stage renal disease ESRD is a vulnerable and challenging period of time for patients and providers. Suboptimal control of blood pressure is known to be common in patients with the advanced stages of CKD, and may contribute to their elevated risk of progression to ESRD, cardiovascular morbidity, and mortality. This proposal is a pilot randomized controlled trial designed to test whether intensive blood pressure lowering is feasible and safe in patients with advanced CKD as they transition to ESRD.
Description
The transition from advanced chronic kidney disease (CKD), when estimated glomerular filtration rate (eGFR) is <30 mL/min/1.73m2, to end-stage renal disease (ESRD) represents a vulnerable period, when multiple physiologic and psychosocial changes occur as patients prepare for either dialysis or kidney transplant. This study is a pilot randomized controlled trial to test the safety and feasibility of studying strict versus usual BP control in a population of patients with advanced CKD (eGFR <30 mL/min/1.73m2), including those with diabetes. For this pilot study, we will randomize 60 patients with advanced CKD who have elevated BP to either a home SBP target of <120 mm Hg (intervention group) versus 130-140 mm Hg (usual care group).
Details
| Condition | chronic renal insufficiency, Chronic renal failure, Vascular Diseases, Hypertension, Blood Pressure, Diabetes and Hypertension, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Elevated Blood Pressure, chronic kidney disease, chronic kidney disease (ckd), high blood pressure, arterial hypertension |
|---|---|
| Treatment | Strict blood pressure control |
| Clinical Study Identifier | NCT02975505 |
| Sponsor | University of California, San Francisco |
| Last Modified on | 25 January 2021 |
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