Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users

  • days left to enroll
  • participants needed
  • sponsor
    Wayne State University
Updated on 25 January 2021
cannabis use


The purpose of the proposed study is to examine the relationship between marijuana reminders, or "cues", craving for marijuana, and marijuana use. The principal investigator is also assessing whether N-acetylcysteine, can reduce marijuana craving or use.


This study involves three screening sessions that could last about 3 hours each.

Part of this study will be conducted on an inpatient unit where the participant will live for 4 straight nights.

During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank). Participants will be asked to take capsules that could contain N-acetylcysteine or placebo (blank).

Participants will be asked to complete questionnaires and have vital signs (blood pressure, heart rate) monitored.

Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).

Condition Drug abuse, Cannabis Dependence, Substance Abuse, Drug use, marijuana abuse
Treatment N-Acetyl Cysteine
Clinical Study IdentifierNCT03154580
SponsorWayne State University
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Participants will be healthy individuals 21-55 year olds who use marijuana
Marijuana use will be verified by self-report and THC-positive urine samples. -Participants must meet DSM 5 criteria for Cannabis Use Disorder and be willing to participate in research but not seeking treatment

Exclusion Criteria

Candidates with the following conditions will be excluded
Serious psychiatric illness (e.g. psychotic or bipolar disorder
Recent (past 5 years) suicide attempts
Major depression that is not substance-induced)
Substance Use Disorders (SUD) other than Cannabis or Nicotine Use Disorders and Mild Alcohol Use Disorder
Neurological diseases (e.g. stroke, seizures)
Cardiovascular problems (e.g. myocardial infarction, angina, systolic BP >160 or <95 mmHg, diastolic BP >95 mmHg, clinically abnormal ECG)
Pulmonary diseases (e.g. asthma, TB)
Systemic diseases (e.g. hepatitis, autoimmune, Cushing syndrome)
Cognitive impairment (<80 IQ)
Past-month exposure to medications that increase study risk (e.g. toxicity to major organs, asthma inhalers)
Women who are pregnant (urine HCG), lactating (self-report), or if heterosexually active and not using (self-report) medically approved birth control measures (oral/depot contraceptives, IUD, condom/foam, sterilization, tubal ligation)
Seeking treatment for a Substance Use Disorder
Individuals unable to give voluntary informed consent will be excluded. Applicants interested in treatment will be excluded from the study and referred to a treatment program
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