Last updated on August 2020

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Squamous cell carcinoma | Vulvar Dysplasia and Carcinoma | Metastatic Melanoma | Precancerous Conditions | Xeroderma Pigmentosum | Basal cell carcinoma | skin cancer | melanoma | Carcinoma | Precancerous condition | Advanced Malignancies | Malignant Melanoma
  • Age: Between 1 - 99 Years
  • Gender: Male or Female


Members of the XP families where the proband has previously been evaluated at the Clinical Center or is newly diagnosed under other approved protocols (primarily 99-C-0099) are eligible to participate in this study. Families with XP patients of any age, gender or race are eligible for this study.

  • On referral, patients with XP and families of XP patients will be considered for inclusion in the study if the proband has clinical documentation of features of XP and laboratory determination of the DNA repair defect. All relatives of XP patients including spouses are eligible to participate. A spouse of a blood relative of a patient with xeroderma pigmentosum would also be eligible.
  • Ability of patient or Legally Authorized Representative (LAR) to sign a written informed consent document


-Inability or unwillingness to provide family history information or tissue (skin, blood, buccal cells or hair) for laboratory studies.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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