MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH) (DepiSCARRH)

  • STATUS
    Recruiting
  • End date
    Mar 27, 2034
  • participants needed
    167
  • sponsor
    Institut Curie
Updated on 24 February 2022
cancer
beam radiation
bilateral retinoblastoma
second primary cancer

Summary

The purpose of this study is to assess the benefit of MR screening for asymptomatic head & neck (or CNS) second primary cancers occurring in hereditary retinoblastoma patients previously treated by external beam radiation therapy (EBRT).

Description

Patients with hereditary retinoblastoma treated during infancy by external beam radiation therapy (EBRT) the risk of second primary cancer occurring within radiation fields is high. The aim of this study is to depict by MRI secondary tumors as early as possible, before the occurrence of clinical symptoms. Affected patients will be further managed in a national expert center with dedicated diagnostic and treatment procedures. However, the benefit of such management has to be assessed in terms of prognosis.

Details
Condition Hereditary Retinoblastoma
Treatment MRI
Clinical Study IdentifierNCT03026998
SponsorInstitut Curie
Last Modified on24 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Personal history of hereditary retinoblastoma (i.e., familial history of retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma, or identified germline RB1 mutation or 13q deletion)
External beam radiation therapy (EBRT) used for retinoblastoma treatment
Age at inclusion greater or equal to 7 years old
Time period between the end of EBRT and inclusion date of 5 years or more
Written informed consent signed by patient (or legal representative)

Exclusion Criteria

Personal history of non-familial unilateral unifocal retinoblastoma without RB1 germline mutation
Personal history of second primary neoplasm occurring within radiation fields
Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators or other implanted electronic devices, intracranial ferro-magnetic clips) or associated conditions preventing from MR examination (intraocular prostheses and implants are not a contraindication for MRI; orthodontic metallic devices are not a contraindication but might decrease the image quality and should be removed, if possible)
Patients unable to comply with follow-up study requirements, for any geographical, social or psychological reason
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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