Last updated on February 2020

MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH)


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Retinoblastoma
  • Age: Between 7 - 35 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Personal history of hereditary retinoblastoma (i.e., familial history of retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma, or identified germline RB1 mutation or 13q deletion)
  • External beam radiation therapy (EBRT) used for retinoblastoma treatment
  • Age at inclusion between 7 and 35 years
  • Time period between the end of EBRT and inclusion date of 5 years or more
  • Written informed consent signed by patient (or legal representative)

Exclusion Criteria:

  • Personal history of non-familial unilateral unifocal retinoblastoma without RB1 germline mutation.
  • Personal history of second primary neoplasm occurring within radiation fields
  • Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators or other implanted electronic devices, intracranial ferro-magnetic clips) or associated conditions preventing from MR examination (intraocular prostheses and implants are not a contraindication for MRI; orthodontic metallic devices are not a contraindication but might decrease the image quality and should be removed, if possible)
  • Patients unable to comply with follow-up study requirements, for any geographical, social or psychological reason

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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