Prospective Investigation of Multiple Sclerosis in the Three Rivers Region (PROMOTE)

  • End date
    Jan 16, 2047
  • participants needed
  • sponsor
    University of Pittsburgh
Updated on 24 February 2022
chronic disease
neurological disorder
disease or disorder
Accepts healthy volunteers


In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.


Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.

Condition Multiple Sclerosis
Clinical Study IdentifierNCT02994121
SponsorUniversity of Pittsburgh
Last Modified on24 February 2022


Yes No Not Sure

Inclusion Criteria

Inclusion criteria for MS patients include
willing and able to give consent
age 7 years or older
diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
For healthy controls
Age 7 years or older
Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
No known personal history of multiple sclerosis or related disorders
No other chronic diseases
Family members, unrelated household controls, or controls from the general population could be eligible
There is no exclusion criteria
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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