Repairing the Defect of Intervertebral Disc With Autologous BMSC and Gelatin Sponge After Microendoscopic Discectomy for Lumbar Disc Herniation

  • End date
    Dec 29, 2022
  • participants needed
  • sponsor
Updated on 24 February 2022
conservative management


In this prospective study the investigators seek to evaluate clinical outcomes after repairing the defect of intervertebral disc with autologous BMSC/gelatin sponge during microendoscopic discectomy for participants of lumbar disc herniation.


The participants with lumbar disc herniation diseases are treated by Microendoscopic discectomy, and they are divided into four groups depend on whether the defect is repaired with Autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge or not and whether the defect is sutured or not. In the first group,the defect of intervertebral disc is repaired with Autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge and sutured. In the second group, the defect of intervertebral disc is repaired with autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge but not sutured after discectomy. In the third group, the defect of intervertebral disc is sutured but not repaired with autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge after discectomy. In the four group, the defect of intervertebral disc is neither sutured nor repaired with autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge after discectomy.

Condition Lumbar Disc Herniation
Treatment Autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge, The defect is sutured
Clinical Study IdentifierNCT03002207
Last Modified on24 February 2022


Yes No Not Sure

Inclusion Criteria

Participants with signs and symptoms of lumbar disc herniation requiring surgical treatment after conservative management
Radiological data on CT/MRI obtained within a period prior to enrollment
Participants give written informed consent before enrollment

Exclusion Criteria

If participants had an incomplete medical record
Participants had spine tumor, spine infection, previous underwent lumbar surgery, or revision surgery
Participants are taking uninterruptible anticoagulation therapy
Dementia and/or inability to give informed consent
MRI contraindication (e.g. cerebral aneurysm clips, cochlear implants, pacemaker, implanted biostimulators)
Participation in other clinical trial within the last 30 days
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