Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia (PROGRESS)
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- STATUS
- Recruiting
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- End date
- Jan 31, 2024
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- participants needed
- 60
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- sponsor
- Babbette Lamarca
Summary
The purpose of this study is to learn if giving 17-hydroxyporgesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.
Description
The OBGYN house and attending staff on duty caring for the patient will determine appropriateness for study inclusion. The treating physician will then immediately contact the MFM fellow on call and Research Division personnel to facilitate the initiation of study procedures, including the consent process and baseline blood tests. Once enrolled with informed consent, the participant will receive 17 OHPC, 250mg IM to be given at admission and every 7 days thereafter. Blood sampling of approximately 1-2 teaspoons each will be collected at baseline immediately prior to administration of 17 OHPC, then 24 hours (+-2hrs). After the first 24 hours, blood samples will be collected every 72 hrs until delivery and again 24hrs (+- 2hrs) after delivery. Placentas will be collected at delivery and the investigators will also collect information of the mother and newborn while in the hospital and until discharge including de-identified routine ultrasound.
Details
| Condition | Pregnancy |
|---|---|
| Treatment | 17 OHPC |
| Clinical Study Identifier | NCT02989025 |
| Sponsor | Babbette Lamarca |
| Last Modified on | 21 March 2022 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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