Last updated on May 2019

Project 3 Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Tobacco abuse
  • Age: Between 18 - 70 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Male or Female
  • Ages 18-70
  • Past-year major depressive disorder, dysthymic disorder, generalized anxiety disorder, post-traumatic stress disorder, obsessive-compulsive disorder, phobia, or panic disorder with or without agoraphobia, based on MINI structured interview, OR lifetime diagnosis of one of the above based on MINI with a self-report of currently receiving treatment (prescribed psychoactive medication, behavioral therapy, etc.)
  • Report smoking 5 or more cigarettes per day for the past year
  • Provide an intake breath CO sample > 8 ppm
  • Be without current substance abuse/dependence other than nicotine
  • Be sufficiently literate to complete the research-related tasks
  • Be in good physical health without serious illness or change in health in the past 3 months as determined by the licensed medical professional at each site
  • Not pregnant or nursing and report using oral, implant, patch, ring, IUD, injection or barrier contraceptives or report being surgically sterile or post-menopausal
  • Report no significant use of other tobacco or nicotine products within the past month (> 9 days in the past 30)

Exclusion Criteria:

  • Any prior regular use (used as primary cigarette outside of the laboratory) of Spectrum cigarettes (i.e., research cigarettes with reduced nicotine content)
  • Exclusive use of roll-your-own cigarettes
  • Planning to quit smoking in the next 30 days
  • A quit attempt in the past 30 days resulting in > 3 days of abstinence
  • Positive toxicology screen for illicit drugs not including marijuana (participants with valid prescriptions will not be excluded and participants with a positive toxicology screen will be allowed to re-screen once)
  • Breath alcohol level > 0.01 (participants with a positive screen will be allowed to re-screen once)
  • Self-report of binge drinking alcohol (> 9 days in the past 30, 4/5 drinks in 2 hours for women/men
  • Systolic blood pressure below 90 mmHg or greater than or equal to 160 mmHg (participants outside the range will be allowed to re-screen once)
  • Diastolic blood pressure below 50 mmHg or greater than or equal to 100 mmHg (participants outside the range will be allowed to re-screen once)
  • Breath CO > 80 ppm
  • Heart rate below 45 or greater than or equal to 115 bpm (participants outside the range will be allowed to re-screen once)
  • Currently seeking treatment for smoking cessation
  • Have used nicotine replacement, bupropion or other pharmacotherapies as cessation aids in the past month (bupropion for treatment of depression will be allowed)
  • Unstable psychiatric conditions (psychiatric medication changes in the past 4 weeks)
  • Current symptoms of psychosis, dementia or mania
  • Suicidal ideation in past month
  • Suicide attempt in past 6 months
  • Participation in another research study in the past 30 days

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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