Raltitrexed-based Chemotherapy Plus Bevacizumab in Retreated Patients With Advanced Colorectal Cancer

  • End date
    Feb 15, 2023
  • participants needed
  • sponsor
    Jiangsu Cancer Institute & Hospital
Updated on 5 September 2021


The objective is to investigate the efficacy and safety of raltitrexed-based chemotherapy plus bevacizumab in the treatment of advanced colorectal cancer

Condition Advanced Colorectal Cancer
Treatment bevacizumab, Irinotecan, Oxaliplatin, raltitrexed
Clinical Study IdentifierNCT03126071
SponsorJiangsu Cancer Institute & Hospital
Last Modified on5 September 2021


Yes No Not Sure

Inclusion Criteria

-70 years
histological and/or cytological confirmation of ACC
disease progression while on first-line palliative fluoropyrimidine-based chemotherapy or relapse within 6 months after adjuvant chemotherapy
at least one measurable objective tumor lesion by spiral CT examination, the maximum diameter 1cmaccording to RECIST 1.1
ECOG performance status 0-1
life expectancy of at least 3 months
satisfactory main organ functionlaboratory test must meet the following criteria: hemoglobin (HGB) 90g/L, neutrophil countANC 1.5109/L, platelet countPLT 80109/L, Serum creatinineCR1.5 upper normal limitation (UNL)total bilirubin (TBil) 1.5 upper normal limitation (UNL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 2.5 UNL (For patients with liver metastasis, the AST/ALT must be 5.0 UNL), Alkaline phosphataseALP3 UNL(For patients with liver metastasis, the ALP must be 5.0 UNL)
written informed consent

Exclusion Criteria

prior exposure to raltitrexed
Clinically significant cardiovascular disease, for example symptomatic coronary artery disease, myocardial infarction (<=6 months before treatment start),congestive heart failure New York Heart Association NYHA>= grade 3,stroke or transient ischemic attack
Accept kidney dialysis treatment now
chronic enteropathy on unresolved bowel obstruction
previous malignant disease other than carcinoma in situ of the cervix or basal cell carcinoma of the skin
the UGT1A1 _287/7_ 6A/A gene type
pregnant or lactated women
Unsuitable for the study or other chemotherapy determined by investigator
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note