Last updated on April 2019

Influence of Intestinal Microbiota Implantation in Preterm Infants on Microbiota and Immune Orientation at 3 Years

Brief description of study

The main objective of this research is to study the links between changes in the intestinal microbiota (in terms of diversity) during the first 6 weeks of life for preterm infants and the presence / absence of a TH1 immune status at 36 months of age.

Detailed Study Description

The secondary objectives are to study the links between changes of the intestinal microbiota premature infants in terms of:

  • changing diversity of the microbiota in the first 6 weeks of life;
  • changes in the bacterial community (UniFrac study) during the first 6 weeks of life;
  • diversity of the microbiota up to 6 weeks;


  • diversity of the microbiota at 1, 2 & 3 years;
  • bacterial communities (UniFrac study) at 1, 2 & 3 years;
  • lymphocyte subpopulation profiles at 3 years;
  • serum immunoglobulin A, G, M, E levels at 3 years;
  • history of infectious episodes, allergic and inflammatory episodes during the first 3 years of life.

The links between certain variables known in the literature and neonatal microbiota will be confirmed / studied in our population:

  • mode of delivery;
  • length (and type) of antibiotic therapy in the neonatal period;
  • duration of breastfeeding.

Clinical Study Identifier: NCT02738411

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Recruitment Status: Open

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