Last updated on March 2020

Predictive Value of Biomarkers of the Alzheimer's Disease (AD) in Elderly Patients With New-onset Epilepsy

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Epilepsy | Seizure Disorders | Seizure Disorders (Pediatric)
  • Age: Between 60 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age 60 years
  • Patients with newly diagnosed epilepsy according to the latest criteria of the International League against Epilepsy.
  • MMSE 28/30.
  • Patients with or without cognitive complaints.
  • Patients whose brain MRI did not reveal significant abnormalities outside slight cortical atrophy.
  • Patients in whom the lumbar puncture did not revealed abnormalities suggestive of an infectious disease or a limbic encephalitis.
  • Patient with adequate visual and auditory skills, an oral and written language in French available to clinical and neuropsychological assessment.
  • Patient who have given its written consent.

Exclusion Criteria:

  • Previous history of epilepsy before age 60 years.
  • Patient with against-indication to MRI (pacemaker, ferromagnetic clips, mechanical heart valves, intra-cochlear implants, intraocular foreign body, skin or other) or refusing MRI.
  • Presence of an abnormality in brain MRI.
  • Patients with diagnostic criteria for dementia of Alzheimer's disease, vascular dementia, mixed dementia or frontotemporal lobar degeneration.
  • Patients with autoimmune encephalitis.
  • Patients under legal protection measure

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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