Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder

  • STATUS
    Not Recruiting
  • participants needed
    20
  • sponsor
    Yale University
Updated on 26 May 2021
anxiety
antidepressants
scid
structured clinical interview
selective serotonin reuptake inhibitors
anxiolytic
anxiety disorder
vdrl

Summary

The goal of the current proposal is to examine if sublingual riluzole can reduce anxiety in people with social anxiety disorder during a public speaking task.

Description

The investigators propose conducting a double-blind, placebo controlled crossover study examining the effects of BHV-0223 on public speaking anxiety. Twenty participants with DSM-5 defined social anxiety disorder and clinically significant public speaking anxiety on the Impromptu Speech Task will be enrolled in a challenge study. Participants will be given BHV-0223 (or placebo) under double-blind crossover conditions 1 hour prior to performing each of 2 impromptu speech tasks. The two study days involving BHV-0223 (or placebo) administration and impromptu speech task will be separated by 2 to 10 days to allow for medication washout. There will be a final follow-up visit 2 to 10 days later to perform a complete Physical exam and do follow-up liver function testing and a Complete Blood Count. Our primary outcome will examine BHV-0223's effects (compared to placebo) on self-rated anxiety during the impromptu speech task. The investigators will also collect physiological measures of anxiety, clinician-rated measures of anxiety, and measures of speech performance as secondary outcomes.

Details
Condition Claustrophobia, Performance Anxiety
Treatment Placebo, BHV-0223
Clinical Study IdentifierNCT03017508
SponsorYale University
Last Modified on26 May 2021

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