Intraosseous Administration of Mesenchymal Stromal Cells for Patients With Graft Failure After Allo-HSCT

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    20
  • sponsor
    National Research Center for Hematology, Russia
Updated on 22 January 2021

Summary

Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after allogeneic bone marrow (BM) transplantation. Since only few MSCs reach the BM after intravenous injection, MSCs were implanted into the iliac spine. Preliminary results suggest that MSCs participate in the restoration of niches for donor hematopoietic cells or have an immunomodulatory effect, preventing repeated rejection of the graft. Perhaps intraosseous implantation of MSCs contributes to the success of the second transplantation of hematopoietic stem cells and patient survival.

Details
Condition Mesenchymal Stem Cell Transplantation
Treatment MSC administration (intraosseal)
Clinical Study IdentifierNCT03389919
SponsorNational Research Center for Hematology, Russia
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

All patients with primary graft failure after allo-HSCT
Available MSC for this patient

Exclusion Criteria

N/A
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