Intraosseous Administration of Mesenchymal Stromal Cells for Patients With Graft Failure After Allo-HSCT
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- STATUS
- Recruiting
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- End date
- Dec 31, 2022
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- participants needed
- 20
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- sponsor
- National Research Center for Hematology, Russia
Summary
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after allogeneic bone marrow (BM) transplantation. Since only few MSCs reach the BM after intravenous injection, MSCs were implanted into the iliac spine. Preliminary results suggest that MSCs participate in the restoration of niches for donor hematopoietic cells or have an immunomodulatory effect, preventing repeated rejection of the graft. Perhaps intraosseous implantation of MSCs contributes to the success of the second transplantation of hematopoietic stem cells and patient survival.
Details
| Condition | Mesenchymal Stem Cell Transplantation |
|---|---|
| Treatment | MSC administration (intraosseal) |
| Clinical Study Identifier | NCT03389919 |
| Sponsor | National Research Center for Hematology, Russia |
| Last Modified on | 24 February 2022 |
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