The Neurobiological Effect of 5-HT2AR Modulation

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    Gitte Moos Knudsen
Updated on 24 January 2021


The investigators wish to investigate neurobiological effects of serotonin 2A receptor modulation in healthy volunteers, contrasting effects of an agonist (psilocybin) and an antagonist (ketanserin). Magnetic resonance imaging (MRI) and positron emission tomography (PET) will be used as neuroimaging tools.

Condition Basic Science
Treatment Psilocybine, Psilocybine, Ketanserin, Ketanserin
Clinical Study IdentifierNCT03289949
SponsorGitte Moos Knudsen
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Healthy individuals above 18 years of age

Exclusion Criteria

Presence of or previous primary psychiatric disease (DSM axis 1 or WHO ICD-10 diagnostic classifications) or in first-degree relatives
Previous or present neurological condition/disease, significant somatic condition/disease or intake of drugs suspected to influence test results
Non-fluent Danish language skills
Vision or hearing impairment
Previous or present learning disability
Contraindications in regard to MRI scanning
Alcohol or drug abuse
Allergy to test drugs
Participation in studies in which participant has received more than 10 mSv of radiation or other significant exposure to radiation
Abnormal ECG or intake of QT prolonging medication
Previous significant side-effects in regard to hallucinogenic drugs
Use of hallucinogenic drugs 6 months previous to inclusion
Blood donation 3 months before and after project participation
Bodyweight under 50 kg
Plasma ferritin levels outside normal range
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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