Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial

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  • sponsor
    University Medical Center Goettingen
Updated on 23 January 2021
antibiotic therapy
urinary urgency
recurrent urinary tract infection


It is well known that "over-treatment" of straightforward infections should be avoided as far as possible. Evidence-based data on non antibiotic treatment options for common conditions are therefore needed urgently. This randomised-controlled double blind trial examines whether initial herbal treatment with Uva Ursi, and antibiotic treatment only if symptoms persist, reduces antibiotic consumption in uncomplicated urinary tract infections (UTI) without a negative effect on symptom course and rate of recurrent UTIs. In total, 430 patients presenting with typical UTI symptoms will be included by their GPs and receive randomised either herbal treatment with uva ursi (antibiotics only if symptoms persist), or initial antibiotic treatment. Patients record symptom severity and drug intake in a diary and complete a final questionnaire after 28 days.

Condition Urinary tract infection
Treatment Arctuvan, Fosfomycin, Fosfomycin, Placebo to Arctuvan, Placebo to Fosfomycin
Clinical Study IdentifierNCT03151603
SponsorUniversity Medical Center Goettingen
Last Modified on23 January 2021

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