Last updated on February 2018

Psycho-biological Substrates of Therapeutic Benefit of Thermal Cure on Generalized Anxiety Disorders


Brief description of study

Multicenter study comparing paroxetine (n=30) versus thermal cure (n=30) in patients with a diagnosis of Generalised Anxiety Disorders

Detailed Study Description

Multicenter study comparing paroxetine (n=30) versus thermal cure (n=30) in patients with a diagnosis of Generalised Anxiety Disorders

Main objective is to quantify the therapeutic benefit of a thermal cure on generalized anxiety disorders and to understand the psycho-biological substrates of this improvement.

Secondary objectives:

  • A decrease of Insula activity at rest during the answers to aversive pictures and during the task of subjective measurement of heartbeat.
  • A decrease of sensibility to emotional interference by subliminal presentation of emotional words thanks to a lexical task and a color recognition task associated to simultaneous measurement of physiological indicator of emotional activity ( dermal resistance)

Clinical Study Identifier: NCT03277339

Contact Investigators or Research Sites near you

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Nematollah Jaafari, PU-PH

Centre Hospitalier Henri Laborit
Poitiers, France
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DUBOIS Olivier, MD

Les thermes de Saujon
Saujon, France
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Recruitment Status: Open


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