Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children

  • STATUS
    Not Recruiting
  • participants needed
    140
  • sponsor
    University of Oulu
Updated on 5 December 2022
antibiotic therapy
antibiotics
amoxicillin
secretory otitis media
pneumatic otoscopy
otoscopy
clavulanate
co-amoxiclav
macrolide
respiratory infection
allergy to amoxicillin

Summary

This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. The participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. The children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. The main outcomes of this trial are the changes in the intestinal microbiome after the treatment.

Description

Antimicrobial treatment of acute otitis media has been proven efficacious in children. It has been suggested that antimicrobial treatment makes a lot of harm to intestinal microbiome and may thus have effects on the child's health and wellbeing. However, data on these changes and their magnitude is scanty. This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. The participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. The children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. The main outcomes of this trial are the changes in the intestinal microbiome after the treatment.

Details
Condition Acute Otitis Media
Treatment Amoxicillin, Amoxicillin-Potassium Clavulanate, Macrolide, Macrolide
Clinical Study IdentifierNCT02935374
SponsorUniversity of Oulu
Last Modified on5 December 2022

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