This is a multi-site, randomized, open-label, effectiveness trial comparing three treatment
arms for Major Depressive Disorder (MDD) patients with TRD who are currently on ongoing,
stable and adequate antidepressant therapy (ADT). Adequate ADT is defined as a
therapeutically sufficient dose for a sufficient treatment period, which would be expected to
be effective as listed in the MGH Antidepressant Treatment Response Questionnaire (ATRQ).
Patients will be randomized in a 1:1:1 fashion to one of three open-label treatment arms: a)
aripiprazole augmentation, b) rTMS augmentation, and c) switching to venlafaxine XR or
Treatment Resistant Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS)
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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