Last updated on May 2018

IMPI 2 - A Trial of Intrapericardial Alteplase in Large Pericardial Effusion


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Pericardial effusion
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Age 18 years of age;
  2. Confirmed large pericardial effusion on echocardiography (i.e., echo free space 1 cm anterior to the right ventricle of the heart in diastole);
  3. Willingness to participate for the full duration of the trial (i.e., 12 months); and
  4. Provision of written informed consent.

Exclusion Criteria:

  1. Age < 18 years;
  2. Uraemic pericarditis (i.e., urea > 21.4 mmol/l);
  3. Thrombocytopenia (i.e., < 100,000 platelets per l);
  4. Presence of a contra-indication to the administration of a fibrinolytic agent (i.e., major haemorrhage or major trauma; coincidental stroke; major surgery in the previous 5 days; blood pressure >200/100 mmHg).

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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