Last updated on March 2019

Bevacizumab Alone Versus Dose-dense Temozolomide Followed by Bevacizumab for Recurrent Glioblastoma Phase III

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Glioblastoma Multiforme | Disease Progression | Relapse
  • Age: Between 20 - 75 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Histologically proven diagnosis of glioblastoma (including giant cell glioblastoma and gliosarcoma).
  2. For patients who did not undergo surgery for recurrent disease; pre-registration contrast MRI should confirm; (i)progressive or recurrent glioblastoma; (ii)no evidence of acute or subacute cerebral hemorrhage at enrolment; (iii)presence of a measurable lesion.
  3. For patients who underwent surgery for recurrent disease; (i)progressive or recurrent glioblastoma must be confirmed on contrast MRI before reoperation; (ii)glioblastoma or anaplastic astrocytoma must be histologically identified in the tissue resected at reoperation; (iii)presence of measurable lesions is not mandatory on pre-registration contrast MRI (more than 4 days after reoperation); (iv)no MRI evidence of aggravating cerebral hemorrhage.
  4. No evidence of tumors in the cerebellum, brain stem, optic nerve, olfactory nerve, and pituitary gland.
  5. No evidence of meningeal dissemination or gliomatosis cerebri.
  6. Prior treatment for newly-diagnosed glioblastoma (or anaplastic astrocytoma) with postoperative TMZ administered concomitantly with radiotherapy (>=54 Gy for <=69 years old; >=30 Gy for >=70 years old) and at least for two cycles (5/28d) as an adjuvant treatment have been given.
  7. No history of prior treatment with stereotactic radiotherapy (ex. Gamma-knife/Cyberknife), proton beam irradiation, neutron capture therapy, and chemotherapies except standard dose TMZ and intraoperative placement of carmustine wafers for .glioblastoma.
  8. More than 90 days after completion of radiotherapy. For those who underwent reoperation, between 21 and 28 days postoperatively.
  9. Age between 20 and 75 years at enrolment.
  10. Karnofsky Performance Status >= 60 within 14 days before enrolment.
  11. No prior treatment with chemotherapy, molecular targeted therapy, or radiotherapy to head and neck area for other malignancies.
  12. Adequate organ function.
  13. Written informed consent.

Exclusion Criteria:

  1. Synchronous or metachronous (within 5 years) malignancy, except for carcinoma in situ or mucosal tumors curatively treated with local therapy
  2. Active infection requiring systemic therapy
  3. Body temperature >= 38 degrees Celsius at registration
  4. Women during pregnancy, possible pregnancy, within 28 days after delivery, or breast-feeding
  5. Psychosis or with psychotic symptom
  6. Continuous systemic use of immunosuppressant except for steroid
  7. Uncontrolled diabetes mellitus or routine administration of insulin
  8. Unstable angina within 3 weeks, with a history of myocardial infarction within 6 months, or New York Heart Association (NYHA) class II or greater congestive heart failure
  9. Inadequately controlled hypertension (cannot be controlled to a systolic pressure of >= 150 mmHg and a diastolic pressure of >= 100 mmHg)
  10. History of symptomatic cerebrovascular disorder (including subarachnoid hemorrhage, cerebral infarction and transient ischemic attack) within 6 months or history of vascular disorder requiring intervention (including venous/arterial thrombosis or embolism and aortic aneurysm) within 6 moths
  11. History of grade >= 2 hemoptysis within 28 days
  12. History of hemorrhagic tendency (e.g., coagulation disorder) or any grade >= 3 hemorrhage within 28 days
  13. History of gastrointestinal perforation, fistula, abdominal abscess or uncontrolled peptic ulcer within 6 months
  14. Interstitial pneumonia, pulmonary fibrosis, or severe lung emphysema
  15. Severe non-healing wound or traumatic fracture at enrolment
  16. Hypersensitivity to Chinese Hamster Ovary-derived drugs or other recombinant antibodies
  17. Gadolinium allergy
  18. Positive HIV antibody
  19. Positive Hepatitis B (HB)s antigen

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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