uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung

  • STATUS
    Recruiting
  • End date
    Oct 21, 2023
  • participants needed
    120
  • sponsor
    Rigshospitalet, Denmark
Updated on 21 January 2021
cancer
carcinoma
lung cancer
lung carcinoma

Summary

uPAR PET/CT as a prognostic marker in non-small cell lung cancer.

Description

Study I: uPAR PET/CT with 68Ga-NOTA-AE105 will be evaluated as a prognostic tool in patients with non-small cell lung cancer (NSCLC) (stage IV (Ia) operable disease (Ib)) by observer-blinded readings and compared to the prognostic performance of FDG PET/CT and prognostic biomarkers as uPAR.

Furthermore, uPAR PET/CT will be evaluated in a pilot study in patients with malignant pleural mesothelioma (MPM) (Study II) and large cell neuroendocrine carcinoma of the lung (LCNEC) (Study III) and correlated with immunohistochemical uPAR expression.

Details
Condition Non-Small Cell Lung Cancer, Malignant Pleural Mesothelioma, Pleural Mesothelioma, Large Cell Neuroendocrine Carcinoma of the Lung, nsclc
Treatment 68Ga-NOTA-AE105 PET/CT
Clinical Study IdentifierNCT02755675
SponsorRigshospitalet, Denmark
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Study I
Histologically verified NSCLC (Study I)
Stage IV disease
Operable disease
The participants must be capable of understanding and giving full informed written consent
Study II
Histologically verified MPM (Study II)
The participants must be capable of understanding and giving full informed written consent
Study III
Histologically verified LCNEC (Study III)
The participants must be capable of understanding and giving full informed written consent

Exclusion Criteria

Study I, II, III
Pregnancy
Lactation/breast feeding
Treatment with neoadjuvant chemotherapy
Weight above 140 kg
Allergy to 68Ga-NOTA-AE105
Clear my responses

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