Humanized CAR-T Therapy for Treatment of B Cell Malignancy

    Not Recruiting
  • participants needed
  • sponsor
    Kai Lin Xu; Jun Nian Zheng
Updated on 21 January 2021
Jiang Cao, M.D., Ph.D.
Primary Contact
Affiliated hospital of Xuzhou medical college (6.1 mi away) Contact
hematologic malignancy
cell transplantation


The present study evaluates the safety and efficacy of humanized Chimeric antigen receptor T cells (CAR-T) in treating recurrent or refractory B cell malignancy targeting CD19 with a humanized scFv. All participants will receive autologous chimeric antigen receptor engineered T cells.


CD19 has been extensively evaluated as a therapeutic target for recurrent or refractory B cell malignancy by chimeric antigen receptor T cell therapy, the single chain antibody sequence (scFv) against CD19 derived from a mouse hybridoma was widely employed. However, the immunogenicity of the mouse scFv sequence might be one of the reasons that CAR-T cells cannot persist in vivo for long. In present study investigators replace the mouse-derived scFv with a a humanized one and evaluate its safety and efficacy.

Condition Chronic Lymphocytic Leukemia
Treatment CAR-T
Clinical Study IdentifierNCT02782351
SponsorKai Lin Xu; Jun Nian Zheng
Last Modified on21 January 2021

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