L-Glutamine Therapy for Sickle Cell Anemia
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- STATUS
- Recruiting
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- participants needed
- 80
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- sponsor
- FDA Office of Orphan Products Development
Summary
This is a study to determine the efficacy of L-glutamine as therapy for sickle cell anemia and sickle O-thalassemia.
Description
Sickle cell anemia is one of the most common and devastating hereditary disorders with significant morbidity and mortality affecting individuals of African-American heritage. No safe effective therapy is yet available. An ideal agent would be one that is readily available, effective, and safe even with chronic use. Early studies using L-glutamine in a few patients show promising results. This is an amino acid that has been used widely for other purposes and shown to be safe. Patients are assigned randomly to receive L-glutamine or placebo orally 3 times a day for 24 weeks after which patients will cross over to the other treatment arm for 24 weeks. Clinical parameters, adverse effects attributable to L-glutamine, and physiological parameters will be monitored throughout the study.
Details
| Condition | Anemia, Sickle Cell, Thalassemia |
|---|---|
| Treatment | L-glutamine |
| Clinical Study Identifier | NCT00029887 |
| Sponsor | FDA Office of Orphan Products Development |
| Last Modified on | 7 November 2020 |
Eligibility
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