Treatment of Renal Colic in the Emergency Departement (ED).

  • STATUS
    Recruiting
  • End date
    Dec 1, 2040
  • participants needed
    600
  • sponsor
    University of Monastir
Updated on 26 January 2021
analgesics
opioid
lidocaine

Summary

to evaluate the analgesic effect of a standard dose of intravenous magnesium added to intramuscular diclofenac compared to intravenous lidocaine combined to intramuscular diclofenac or intramuscular diclofenac alone in patients presenting to the emergency department with renal colic and whether it can reduce opioid consumption.

Description

Magnesium (MgSO4) is a N-Methyl-D-aspartate (NMDA) receptor antagonist and is thought to be involved in the modulation of pain. There has been little direct evidence that MgSO4 relieve neuropathic pain and prevents opioid-induced hyperalgesia in humans.

Intramuscular Diclofenac seems to offer the most effective sustained analgesia for renal colic in the ED and has few side effects.

Lidocain became the agent of choice in visceral and central pain. Intravenous lidocain is effective in the management of neuropathic pain such as diabetic neuropathy, post-surgical pain, post herpetic pain, headaches, and neurological malignancies. At low doses, lidocain is known a relatively safe medication. Lidocain seems an effective treatment who can be administrated in the renal colic.

Objective of study :

The aim of this study is to evaluate the analgesic effect of a standard dose of intravenous magnesium added to intramuscular diclofenac compared to intravenous lidocain combined to intramuscular diclofenac or intramuscular diclofenac alone in patients presenting to the emergency department with renal colic and whether it can reduce opioid consumption.

Details
Condition Renal Colic, Pain, Post-Surgical Pain, Pain (Pediatric)
Treatment lidocaine, Diclofenac, Magnesium Sulfate
Clinical Study IdentifierNCT03199924
SponsorUniversity of Monastir
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Informed consent
Age > 18years
Confirmed renal colic
With moderate to severe pain (visual analogic Scale 4)

Exclusion Criteria

Current regular use of analgesics, anticonvulsants, or antidepressants
Analgesia taken within 24 hours
Renal disorder with a low glomerular filtration rate (< 60ml/min)
Neuromuscular disorder
Severe cardiac disease
Pregnant women
Contraindication to one of the protocol treatment
Inability of the patient to cooperate
Allergy to NSAID or lidocaine
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