Last updated on February 2018

Doxycycline for the Treatment of Nodding Syndrome


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Seizure
  • Age: Between 8 - 18 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Participants with confirmed NS as defined by the WHO i.e. Head nodding on two or more occasions (both past and current)
    • Symptom onset between the ages of 3-18 years
    • Observed by a trained health worker or documented on EEG

Plus any one of:

  • Triggered by food or cold weather
  • Presence of other seizures or neurological abnormalities and cognitive decline
  • Clustering in space or time. 2. Age 8 years or older 3. Written consent by the parent or guardian

Exclusion Criteria:

  1. Females with a positive urinary HCG (pregnancy) test
  2. Patients receiving Phenobarbitone, Carbamazepine, Phenytoin or Rifampicin.
  3. Known hypersensitivity to study drug
  4. Withdrawal of consent since enrollment
  5. Reported inability to swallow capsules
  6. Enrolled or known agreement to enroll into another clinical trial involving ongoing or scheduled treatment with medicinal products during the course of the study
  7. Suspected high likelihood of non-compliance with study drug and the follow-up schedule
    • e.g. dependent on a carer who is unlikely to consistently be available.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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