Prevention of Akute Kidney Injury Hearttransplant ANP

  • End date
    Dec 19, 2022
  • participants needed
  • sponsor
    Sahlgrenska University Hospital, Sweden
Updated on 19 March 2021
renal injury


Prospective, blinded, placebo-controlled trial. Patients: Adult patients (>18 years of age) undergoing de novo Htx, with a preoperative GFR > 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of > 6 hours. A donor age > 70 years is an exclusion criteria.

Intervention: Infusion of h-ANP fore five days, starting at the induction of anesthesia.

Outcome: Kidney function, evaluated with serum creatinine day 1-7 and kidney clearance, 4-5 Days after Htx plus after 3 and 12 months.

Condition Renal Failure, Acute renal failure, Kidney Failure (Pediatric), Kidney Failure, acute kidney injury, acute kidney injuries
Treatment Placebo, ANP, ANP
Clinical Study IdentifierNCT02665377
SponsorSahlgrenska University Hospital, Sweden
Last Modified on19 March 2021


Yes No Not Sure

Inclusion Criteria

De novo Htx
Preoperative GFR > 30ml/min/1,73m2
>18 years old
Written consent

Exclusion Criteria

Multi organ transplantation or previous heart transplant
Donor age > 70 years
ABO-incompatible organ
Donor heart ischemia time > 6 tim
Known kidney disease
Other planed study within 2 mounth
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