Last updated on February 2018

Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding

Brief description of study

Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding

Detailed Study Description

A prospective cross sectional study on 150 consecutive patients screening for esophageal varices.

Patient groups groups:

Group (1): 100 patients with esophageal varices

Group (2): 50 chronic liver disease patients with no esophageal varices as a control group.

All patients will be subjected to:

  1. - Detailed history-taking
  2. - Full clinical examination
  3. - Laboratory investigations:
    • Complete blood picture (CBC)
    • Erythrocyte sedimentation rate (ESR)
    • Renal function tests
    • Liver function tests
    • Prothrombin time and activity
    • Viral markers (HCV Ab - HBV Ag)
    • Blood ammonia level.
  4. - Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen, kidney and other abdominal organs.
  5. - Upper GITendoscopy:
    • Varices will be classified according to the Japanese classification 1996,
    • The Baveno 11 score will be used to differentiate between mild and severe portal hypertensive gastropathy.

Clinical Study Identifier: NCT03212872

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